ABSTRACT
O envolvimento cardíaco ocorre em 25 'por cento' a 50 'por cento' dos pacientes com S.I.D.A., quando analisados por ecocardiografia, biópsia miocárdica ou necrópsia. As manifestaçöes clínicas afetam 10 'por cento' dos pacientes, sendo a insuficiência cardíaca a mais frequente. Descrevemos a evolução de um paciente que tinha teste positivo para H.I.V. e miocardite como a primeira manifestação clínica da doença - a miocardite estava associada com arritmias complexas e bloqueio atrioventricular, havendo necessidade de implante de um marcapasso definitivo.
Subject(s)
Humans , Male , Adult , Myocarditis/complications , Myocarditis/diagnosis , Acquired Immunodeficiency Syndrome , Albuterol/administration & dosage , Homosexuality, Male/history , Methylprednisolone/administration & dosageABSTRACT
1. Two proteoglycans, PG1 and PG2, have been isolated from shark cartilage. Both are highly polydisperse and large (molecular mass: 1-10 x 10**6 Daltons) and contain chondroitin sulfate and keratan sulfate side chains, but PG2 is somewhat smaller tham PG1 and contains less keratan sulfate. 2. Monoclonal antibodies were raised against PG1. Many antibodies were obtained and one of them, MST1, was subcloned and furter characterized. This monoclonal antibody reacts with PG1 and PG2 from shark cartilage and also with aggrecan from bovine trachea cartilage. Chondroitinase AC-treated proteglycans react MST1, indicating that the antibody does not reconize chondroitin sulfate. MST1 also recognizes aggrecan from human cartilage and a proteoglycan from bovine brain (neurocan) but it does reconize proteoglycans from rat Walker tumor, fetal calf muscle and decorin from human myoma. 3. Using MST1 we were able to demonstrate that both PG1 aggregate with hyaluronic acid
Subject(s)
Cattle , Mice , Rabbits , Rats , Humans , Animals , Male , Antibodies, Monoclonal/isolation & purification , Cartilage/chemistry , Proteoglycans/chemistry , Antibodies, Monoclonal/biosynthesis , Antibodies, Monoclonal/immunology , Chondroitinsulfatases/chemistry , Chondroitinsulfatases/immunology , Chondroitinsulfatases/isolation & purification , Epitopes , Keratan Sulfate/chemistry , Keratan Sulfate/immunology , Keratan Sulfate/isolation & purification , Proteoglycans/immunology , Proteoglycans/isolation & purificationABSTRACT
Oito pacientes com cardite reumatica ativa a maioria em franca insuficiencia cardiaca foram tratados com esquema de pulsoterapia (lg de metilprednisolona intravenosa). Foram acompanhados por exame clinico,eletrocardiograma, radiografia de torax, provas de atividade reumatica e ecocardiograma. A melhora da insuficiencia cardiaca ocorreu em dias. Esta forma de terapeutica tornou possivel o controle da insuficiencia cardiaca, certamente imunologica em curto periodo de tempo e sem efeitos adversos. Ela permitira, tambem, maior abrangencia em situacoes especiais de insuficiencia cardiaca auto-imune